Melano I, Husni ME, Piuzzi NS, Foo SS, Chen W. Emerging and underrecognized viral triggers of autoimmune inflammatory rheumatic disease flares. Nature Reviews Rheumatology. 2026 Feb;22(2):118-131. PMID: 41360977.

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Fraczek M, Breckenridge H, Melano I, Squillacioti E, Nielsen-Saines K, Recinos V, Chen W. Intracranial calcifications in congenital viral infections: mechanisms and cellular roles. Current Opinion in Virology. 2025; 73:101479. PMID: 40915005.

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Melano I, Azamor T, Caetano CC, Meyer NM, Onwubueke C, Visperas A, Familiar-Macedo D, Salem GM, Soos BL, Calabrese CM, Choi YJ, Chen S, Choi Y, Wu X, Vasconcelos Z, Comhair SA, Nielsen-Saines K, Calabrese LH, Husni ME, Jung JU, Piuzzi NS, Foo SS, Chen W. SARS-CoV-2 ORF8 drives osteoclastogenesis in preexisting immune-mediated inflammatory diseases. JCI Insight. 2024 Dec 20;9(24). PMID: 39704167; PMCID: PMC11665583.​

 

Caetano CCS#, Azamor T, Myer NM, Meyer NM, Onwubueke C, Calabrese CM, Calabrese LH, Visperas A, Piuzzi NS, Husni ME, Foo SS, Chen W. Mechanistic insights into bone remodelling dysregulation by human viral pathogens. 2024, Nature Microbiology. Feb 05; 9(2):322-335. PMID: 38316931; PMCID: PMC11045166.​

 

Azamor T, Familiar-Macedo D, Salem GM, Onwubueke C, Melano I, Bian L, Vasconcelos Z, Nielsen-Saines K, Wu X, Jung JU, Lin F, Goje O, Chien E, Gordon S, Foster CB, Aly H, Farrell RM, Chen W^, Foo SS^. Transplacental SARS-CoV-2 protein ORF8 binds to complement C1q to trigger fetal inflammation. EMBO Journal. 2024 Nov;43(22):5494-5529. PMID: 39390219; PubMed Central PMCID: PMC11574245 (^Co-Corresponding Authors).​

 

Foo SS*, Chen W*, Azamor T*, Jung KL, Cambou MC, Familiar-Macedo D, Salem GM, Melano I, Sim MS, Moreira ME, Brasil P, Vasconcelos Z, Nielsen-Saines K, Jung JU. Sustained chronic inflammation and altered childhood vaccine responses in children exposed to Zika virus. EBioMedicine. 2024 Aug 1;106:105249. PMID: 39024898; PMCID: PMC11304698.​

 

Chen W, Foo SS, Hong E, Wu C, Lee WS, Lee SA, Evseenko D, Moreira MEL, García-Sastre A, Cheng G, Nielsen-Saines K, Brasil P, Avvad-Portari E, Jung JU. Zika virus NS3 protease induces bone morphogenetic protein-dependent brain calcification in human fetuses. Nature Microbiology. 2021;6(4):455-466. PMID: 33510473; PMCID: PMC8012254.

 

Foo SS*^, Chen W*^, Chan Y, Lee WS, Lee SA, Cheng G, Nielsen-Saines K, Brasil P, Jung JU^. Biomarkers and immunoprofiles associated with fetal abnormalities of ZIKV-positive pregnancies. JCI Insight. 2018 Nov;3(21). PMID: 30385728; PMCID: PMC6238739 (^Co-Corresponding Authors).​

 

Burt FJ, Chen W, Miner JJ, Lenschow DJ, Merits A, Schnettler E, Kohl A, Rudd PA, Taylor A, Herrero LJ, Zaid A, Ng LFP, Mahalingam S. Chikungunya virus: an update on the biology and pathogenesis of this emerging pathogen. Lancet Infectious Diseases. 2017;17(4):e107-e117. PMID: 28159534.​

 

Chen W, Foo SS, Zaid A, Teng TS, Herrero LJ, Wolf S, Tharmarajah K, Vu LD, van Vreden C, Taylor A, Freitas JR, Li RW, Woodruff TM, Gordon R, Ojcius DM, Nakaya HI, Kanneganti TD, O'Neill LAJ, Robertson AAB, King NJ, Suhrbier A, Cooper MA, Ng LFP, Mahalingam S. Specific inhibition of NLRP3 in chikungunya disease reveals a role for inflammasomes in alphavirus-induced inflammation. Nature Microbiology. 2017;2(10):1435-1445. PMID: 28848230.

 

Chen W, Foo SS, Sims NA, Herrero LJ, Walsh NC, Mahalingam S. Arthritogenic alphaviruses: new insights into arthritis and bone pathology. Trends in Microbiology. 2015;23(1):35-43. PMID: 25449049.​​

 

Chen W, Foo SS, Taylor A, Lulla A, Merits A, Hueston L, Forwood MR, Walsh NC, Sims NA, Herrero LJ, Mahalingam S. Bindarit, an inhibitor of monocyte chemotactic protein synthesis, protects against bone loss induced by chikungunya virus infection. Journal of Virology. 2015;89(1):581-93. PMID: 25339772; PMCID: PMC4301140.​

 

Burt F*, Chen W*, Mahalingam S. Chikungunya virus and arthritic disease. Lancet Infectious Diseases. 2014;14(9):789-90. PMID: 25164188 (*Co-First Authors).​

 

Chen W, Foo SS, Rulli NE, Taylor A, Sheng KC, Herrero LJ, Herring BL, Lidbury BA, Li RW, Walsh NC, Sims NA, Smith PN, Mahalingam S. Arthritogenic alphaviral infection perturbs osteoblast function and triggers pathologic bone loss. Proceedings of the National Academy of Sciences. 2014;111(16):6040-5. PubMed PMID: 24733914; PMCID: PMC4000821.

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Full list of published work

https://www.ncbi.nlm.nih.gov/myncbi/1bGZZ823Otd5n/bibliography/public/