Our Research
At the JChen Lab, we explore how viruses affect the musculoskeletal system, bone, and neurological function. Using advanced models and molecular tools, we study how viral infections cause calcifications, bone loss, and neuroinflammation. Our goal is to uncover key mechanisms and develop strategies to prevent or treat virus-induced conditions.
We are always looking for motivated PhD students, postdocs, and collaborators to join us in advancing the frontiers of viral pathogenesis research.
Key Research Areas
1. Viral-Induced Calcifications and Neurodevelopment
We study how viral infections during development can lead to brain and cranial abnormalities as well as long-term neurodevelopmental disorders. By combining advanced molecular techniques with in vivo models, we aim to uncover the specific viral mechanisms that disrupt tissue development and neural pathways. This research not only advances our understanding of virus-induced neuropathology but also identifies potential targets for early therapeutic intervention.
2. Viral-Induced Osteoclastogenesis and Bone Loss
We investigate how viruses trigger inflammatory bone loss, osteoclast activation, and chronic arthritis, causing long-term musculoskeletal complications. Using a combination of molecular virology, immunology, and disease modeling, we seek to define the cellular and molecular pathways driving bone pathology. Our ultimate goal is to develop strategies to prevent or treat virus-induced musculoskeletal disease, improving patient outcomes for chronic viral infections.
3. Translational Studies Using a Unique 3D Model System
We utilize a unique 3D system to study human musculoskeletal tissues in a controlled environment. This platform allows us to replicate key features of joint biology and test the impact of viral infections on tissue function. By integrating mechanistic insights with this advanced model, we aim to develop and evaluate potential therapies for virus-induced musculoskeletal disorders, bridging laboratory discoveries with clinical applications.
